Study on the Expression and Mechanism of Tumour-Derived IgG in Prostate Cancer

The lack of effective treatment for CRPC is the leading cause death in prostate cancer patients. However, exhibits high immunoglobulin (Ig) expression. Ig, one most important immune molecules, a unique product B lymphocytes and plays an role defence. expression IgG malignant tumour tissues positively correlated with degree malignancy, promotes proliferation metastasis cells. A retrospective analysis immunohistochemical pathological tissue sections collected from 50 patients (PC) 40 prostatic hyperplasia Yichun City People’s Hospital between May 2010 2014 was conducted. experimental group had average age 70.8 ± 2.7 years (58~86 old) included 12 low Ig 38 survival time former significantly longer than that latter group. In vitro, protein mRNA PC3 cells detected by Western blotting RT-PCR. knocked down via small interfering RNA (siRNA), migration invasion abilities were assessed using Transwell assay. Positive tumour-derived can indicate poor prognosis cancer, cancer. Thus, may become therapeutic target